You must wait at least 14 days after stopping an MAO inhibitor before you take fluoxetine. Seek urgent medical advice if symptoms consistent with serotonin syndrome (such as agitation, hallucinations, fast heart rate, dizziness, flushing, nausea, diarrhea) or Neuroleptic Malignant Syndrome (including high body temperature, muscle rigidity, or mental disturbances) develop. #1 Prozac and Alcohol. WebMD does not provide medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Common medications that may interact with Prozac include: Avoid drinking alcohol or taking illegal or recreational drugs while taking Prozac. You must wait at least 14 days after stopping an MAO inhibitor before you can take fluoxetine. Copyright 1996-2021 Drugs.com. Morning dosages may decrease the risk of insomnia. You must wait 5 weeks after stopping Prozac before you can take thioridazine or an MAOI. Yes I suffer from the same problems as you describe above and have been on and off fluoxetine for several years for major depression and I can reassure you that the side effects as far as increased anxiety at the beginning of treatment are common and I have had to take … Antidepressants are not for me and I have shared about some of my experiences with psych meds. A year after that, she became my psychotherapy patient, and after she successfully completed therapy, we began cutting back on her Prozac prescription. Don't delay your care at Mayo Clinic. 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