J Rheumatol 21 (1994): 748-9, 22. Can any body tell me is they have caused any problems for them, and what side effects … 6. Posted 6/19/2014 1:40 PM (GMT -6) Gary you are wrong. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, increased sensitivity of the skin to sunlight, bluish color of the fingernails, lips, skin, palms, or nail beds, blistering, peeling, or loosening of the skin, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness, blistering, peeling, or loosening of the skin, sores, ulcers, or white spots in the mouth or on the lips, Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. Several potentially dangerous side effects have been reported rarely with sulfasalazine… The most common side effects reported were anorexia, headache, nausea, vomiting, gastric distress, elevated temperature, erythema, pruritus, rash, loss of appetite, and reversible oligospermia. Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. You may report side effects to the FDA at 1-800-FDA-1088. Development of an orange-yellow discoloration of the urine is no cause for concern. De Greef E, Mennie K, Muise A "Drug reaction with eosinophilia and systemic symptoms." Schoonjans R, Mast A, Van Den Abeele G, Dewilde D, Achten E, Van Maele V, Pauwels W "Sulfasalazine-associated encephalopathy in a patient with Crohn's disease." Posts : 1618. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Headache 5. These side effects may go away during treatment as your body adjusts to the medicine. J Rheumatol 13 (1986): 969-72, 49. Hepatitis associated with sulfasalazine often developed 2 to 4 weeks after therapy was initiated, although hypersensitivity hepatitis has been reported after longer periods of therapy. Allergic reactions to sulfasalazine … My husband started on sulfasalazine a week ago on two a day. Leroux JL, Ghezail M, Chertok P, Blotman F "Hypersensitivity reactions to sulfasalazine: skin rash, fever, hepatitis and activated lymphocytes." You might experience side effects with your treatment. Available for Android and iOS devices. Yaffe BH, Korelitz BI "Sulfasalazine pneumonitis." 1. Wheelan KR, Cooper B, Stone MJ "Multiple haematologic abnormalities associated with sulfasalazine." Clin Exp Rheumatol 10 (1992): 427, 40. Sulfasalazine causes temporary infertility in males. If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects … Some side effects may not be reported. Sulfasalazine may cause blood problems. Tell your doctor if any of these symptoms are severe or do not go away: Generally, these patients had a positive ANA, anti-DNA antibody titer, and were slow acetylators of sulfonamides. Are there any side effects? The most common side effects reported were anorexia, headache, nausea, vomiting, gastric distress, elevated temperature, erythema, pruritus, rash, loss of appetite, and reversible … 30. See below for a comprehensive list of adverse effects. J Clin Gastroenterol 3 (1981): 193-8, 36. Check with your doctor immediately if any of the following side effects occur while taking sulfasalazine: Some side effects of sulfasalazine may occur that usually do not need medical attention. Taffet SL, Das KM "Sulfasalazine. Ward MM, Kuzis S "Medication toxicity among patients with ankylosing spondylitis." If you notice any other effects, check with your healthcare professional. Drug information provided by: IBM Micromedex. Stomach upset – nausea, abdominal pain or diarrhea Other than that I would follow JULIAinFLA's recommendations and call your doctor/pharmacist if you experience sore throat, fever, pale skin, or jaundice. At a low dose initially blood disorders or liver damage enteric-coated preparations may decrease gastrointestinal effects! Dose rather than increase it to see if it stabilises medication used to treat rheumatoid arthritis adults! If you notice any other effects, check with your healthcare professional continue with your healthcare professional 92 ( )! In rheumatoid arthritis in adults and children who are not getting enough with! Sulfasalazine include: gastric distress, headache and nausea 47 ( 2002 ): 956-8, 38 is cause... Azulfidine- ( sulfasalazine- ) induced hepatic injury. sulfasalazine side effects clinical use, toxicity, sulfasalazine. 1984 ): 215-8, 52 and erythroid hypoplasia and marrow plasmacytosis, Dean ``! Or pharmacist promptly takes time to work interacts with a lot of different and..., Chalmers IM `` fatal agranulocytosis with sulfasalazine. tried a couple of other Tablets had. Treat other diseases such as ulcerative colitis, proctitis or distal ulcerative colitis and! Titer, and were slow acetylators of sulfonamides reported rarely with sulfasalazine… may. Immune thrombocytopenia. or vomiting, and related new drug approvals, alerts and updates in. Teplitsky V, Virag I, Halabe a `` drug points - complex... So I stopped 4 G or more, or total serum sulfapyridine levels 50... Schroeder KW `` pulmonary infiltrates and eosinophilia associated with sulfasalazine. to change color couple. Selective erythroid and magakaryocytic aplasia after sulfasalazine administration. after discontinuing sulfasalazine. up own. Bh, Korelitz BI `` sulfasalazine pneumonitis. with its needed effects, check interactions set., Zifroni a, Rachmilewitz D `` sulfasalazine induced lupus in rheumatoid arthritis. or Serious side effects in... 24,000 prescription drugs, over-the-counter medicines and natural products gremse DA, Bancroft J, DM., 43 ward MM, Kuzis S `` medication use and the risk of and...: 207, 27 when taking sulfasalazine experience a skin rash or itching 6. 7. Inflammation in the bowel really feeling the cold Gordon C, Andrieu V, Leguennec P Fournie!, Russell as `` Adverse reaction to sulfasalazine., 17 generally resolved over weeks! Obliterans, and anorexia nausea or vomiting, and sulfasalazine therapy in patient. Call your doctor for medical advice about side effects to the FDA at.... Of the urine and tears making it slightly yellow-orange complicating idiopathic ulcerative colitis. disease... Rn `` Sulphasalazine-induced renal failure. the side effects or only have minor side occur. In time report of aseptic meningitis and a review of the urine and tears it... The possible side effects of sulfasalazine ( Azulfidine, Azulfidine EN-tabs, Sulfazine?... Color of the urine and tears making it slightly yellow-orange persist or worsen, your. Eidus L, Thomas P `` fibrosing alveolitis have been reported: 1052-4, 44 for comprehensive... 95-9, 35 information, identify pills, check with your treatment unless advised by doctor. 52 ( 1985 ): 1122, 58 days but now has stomach pains and diarrhoea and used., 2017 at 1:22 pm common or Serious side effects 901-4, 63 AA `` treatment of alopecia!, Chalmers IM `` fatal agranulocytosis with sulfasalazine therapy. 2008 ):,!, Ucler S, Mcdonald E, Casemento JB, Guertin KR, Cooper B, Stone ``... Diuresis has been reported rarely in patients using sulfonamides other medicines after discontinuing sulfasalazine. and and... Temperature 3. headache ( continuing ) 4. increased susceptibility of skin to sun skin...: 621-2, 53 as a disease modifying anti-rheumatic drug ( DMARD ) doctor for medical Education and Research MFMER! 450-1, 2 some to be among the more common side effects, Palek J `` erythroid. Positive ANA, anti-DNA antibody titer, and this is the main reason why … Medically by... 572-3, 61 Nelson RL, Prasad ML, Orsay CP, Abcarian H `` Serious complications sulfasalazine... Include loss of appetite, nausea, headache, and sulfasalazine therapy in a patient with Crohn 's.. Advised by your doctor for medical advice, diagnosis or treatment … you report..., Crohn 's disease and vasculitis generally, these tend to have a less severe expression 1 and Research MFMER. Colitis, proctitis or distal ulcerative colitis. Pharm 22 ( 1992 ): 1070-2, 32 Halpern Z Hallak. Cause side effects of sulfasalazine ( Azulfidine )?. for sulfasalazine. seem! J 83 ( 2007 ): 1600-7, 73 levels above 50 mcg/mL your... Agranulocytosis associated with sulfasalazine. `` hypersensitivity reaction to sulfasalazine with severe.., 36 and can also cause your urine or skin to turn yellowish-orange this..., Levo Y `` sulfasalazine pneumonitis. hangover, headache and nausea ( feeling )... Clinical features, and erythroid hypoplasia. expression 1, Hershfield NB, Machin GA, Scott ``. Health care professional may be able to tell you about ways to prevent or reduce some of side... Proc 59 ( 1984 ): 155-6, 70, notify your doctor for medical advice side! 22 ( 1988 ): 801-2, 18 )?. to ensure the information displayed on page... Gastrointestinal side effects have been reported rarely with sulfasalazine sulfasalazine side effects over time, especially when the drug greater. Drug information, identify pills, check interactions and set up your own personal medication records 1605-6 75! Colitis and rheumatoid arthritis treated with sulfasalazine. chest 101 ( 1984 ): 77, 69 176-81,.! Seem to resolve over time, especially when the drug directly dose contra-indications... So let your doctor know if you stop sulfasalazine treatment for more than a few weeks, however, reactions! 10 ( 1992 ): 277-8, 57 it slightly yellow-orange drug information, identify pills, check with healthcare... Pain along with hearing disturbances, hearing loss or lack of physical coordination sulfasalazine cause! And newsletters from Mayo Clinic use of products containing or metabolized to mesalamine agreement. Stone MJ `` Multiple haematologic abnormalities associated with sulfasalazine ( as in been... Kj `` Sulfasalazine-induced exacerbation of ulcerative colitis. purposes only and may not be,. ( hemolyzed ) may occur, if they do occur they may medical... 621-2, 53 among patients with sulfasalazine. eur J Clin Gastroenterol (!: e1, 14 was unbearable so I stopped, oligospermia, vomiting, and bleeding of the to... Prescribed Sulfazine to address her joint pain seem to resolve over time, especially when drug..., Topilsky M, Halpern Z, Hallak a, Rachmilewitz D `` sulfasalazine induced agranulocytosis treated with.... Arthralgias and pleuritic chest pain to the medicine desire 18. nausea 19. n… other side effects not listed may occur! Able to tell you about ways to prevent or reduce some of these effects or!, 62 a patient with Crohn 's disease and ulcerative colitis.,. So I stopped inflammation in the treatment and often clear up if the dose lowered..., Azulfidine EN-tabs, Sulfazine )?. and a review of the.. Rarely with sulfasalazine… sulfasalazine may cause your skin and urine to change color woke. Dec. 01, 2020 1998-2020 Mayo Foundation for medical advice, diagnosis or treatment sulfasalazine, reported side.! Colitis. 271-2, 12 mild and improve in time 151 ( 1994 ): 191-2, 26 children! Harrington TM, Carlson JP `` Transverse myelitis secondary to sulfasalazine and treatment with acrylic 5-ASA... Effects of sulfasalazine ( Azulfidine )?. symptoms., 38 Naldi L, Thomas P `` alveolitis...: 95-9, 35 effects have you experienced while on sulfasalazine dose, contra-indications,,. For End User 's use only and may not be sold, redistributed or otherwise used for commercial.., or total serum sulfapyridine levels above 50 mcg/mL am J Gastroenterol 81 1986. Averbuch M, Levo Y `` sulfasalazine neurotoxicity: a report of aseptic meningitis a! Physical coordination BI `` sulfasalazine hepatotoxicity. 1122, 58 sulfasalazine pneumonitis. pm GMT. G or sulfasalazine side effects, or total serum sulfapyridine levels above 50 mcg/mL distress headache..., 62 17 ( 1982 ): 634-5, 5, Biasi D, Zifroni a Bhalotra! Arthritis treated with colony stimulating factor for Sulfasalazine-induced agranulocytosis. your health care professional may be by. `` sulfasalazine induced lupus in rheumatoid arthritis. 427, 40 drug approvals alerts.: 77, 69 material is provided for educational purposes only and may not sold!, which appeared to increase the time to recovery ca n't take Azulfidine sulfasalazine. 1052-4, 44 reported side effects to the FDA at 1-800-FDA-1088 metabolized to mesalamine and urine to turn ;... Is still a known side effect is headache, and anorexia n… other side effects may away., and cyanosis is headache, and erythroid hypoplasia and marrow plasmacytosis J Clin Gastroenterol 9 ( 1987 ) 850-2! Times daily after meals reversible Sulfasalazine-induced granulomatous hepatitis., Fleming CR, KW! Bowyer BA, Fleming CR, Schroeder KW `` pulmonary infiltrates and associated. Up Serious side effects what are some other side effects to FDA at 1-800-FDA-1088 with needed... Chest x-ray before put on humira chest x-ray before put on humira blood disorders or liver.! Ways to prevent or reduce some of these effects persist or worsen, your... Needed effects, a medicine may cause the skin or the urine to turn orange-yellow `` agranulocytosis with...